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KMID : 0043320010240060536
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Archives of Pharmacal Research
2001 Volume.24 No. 6 p.536 ~ p.540
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Anti-lipid Peroxidative Principles from the Stem Bark of Kalopanax pictus Nakai
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Choi JW
Han YN/Lee KT/Park KY/Kwak TS/Kwon SH/Park HJ
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Abstract
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Hepatic lipid peroxide contents were examined in bromobenzene-treated rats firstly after the oral administration of MeOH extract of Kalopanax pictus stem bark, its n-BuO H fraction, EtOAc fraction and an alkaline hydrolysate of the n-BuOH fraction, and secondly after the intraperitoneal administration of hederagenin monodesmosides anti bisdesmosides. Leo hederaRenin monodesmosides, kalopanaxsaponin A (KPS-A) and sapindoside C, exhibited significant anti-lipid peroxidation effects after intraperitoneal administration at doses of 10-30mcmole/kg, whereas their bisdesmosides did not exhibit any significant activity. These results suRRest that it is the hederagenin monodesmosides that are responsible for anti-lipid peroxidation in vivo. The activity of KPS-A was established by the obseNation of decreased aminopyrine N-demethy1ase activity and increased epoxide hydrolase activity.
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